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A 57-year-old male was admitted to our Hospital on March 2020 for SARS-Cov2 related interstitial pneumonia. Chest x-ray showed a bilateral interstitial-alveolar pneumonia and Blood gas analysis (BGA) in room air highlighted a severe respiratory failure (pO2 46 mmHg, pH 7.41). D

1.1. Background: Sinus of Valsalva injury, either due to congenital defect or major traumatic events, was known to be rare.

Pigmentation disorders leading to discoloration or hyperpigmentary of underlying tissue occur widely and gain interest. This study is within the framework of strategies under-developing safe compounds to modulate melanognonesis pathway. Phenolic acids and flavones were tested for their effects, on the viability in murine melanoma (B16-F10) and in primary human keratinocyte (PHK).

Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome. In addition, the mutation of Ryanodine receptor 2 (RYR2) gene on chromosome 1 has clarified. Here described is a 7 × 5 cm nodular lesion in segment 4 in a 28-year-old man with ALGS. Through imaging studies and histopathological analysis, the nodule was diagnosed, for the first time, as iron deposit giant nodule. Additionally, a review of previous reports has been made to shed more light on this syndrome.

Preeclampsia is a condition that affects nearly 8% of pregnant women, usually during the second half of pregnancy (from around 20 weeks) or soon after their baby is delivered. A spontaneous subdural hematoma associated with preeclampsia is extremely rare. The author is reporting in this article the case of a 32-year-old woman with 34 weeks of gestation, who sought treatment for high blood pressure, headache, and proteinuria. Nearly 6 weeks after a cesarean delivery of a stillborn baby, the patient developed headache and palsy of the left VIth cranial nerve. Magnetic resonance imaging revealed a left hemispherical subdural hematoma, with midline deviation.

Kawasaki disease (KD) is one of the most common etiologies of acquired heart disease among children worldwide with unknown pathogen. Early recognition and establishing the diagnosis help the clinical pediatrics practitioner delivering intravenous immunoglobulin treatment promptly, which plays the most important part of reducing the risk of developing coronary artery abnormalities.

CleidocranialDysostosis is an autosomal dominant scale dysplasia. We present a case of CleidocranialDysostosis of a female patient with deformities in the development of the osteomyoarticular system due to clavicular agenesis, deficiency in mandibular development and dentition, which was diagnosed very early in childhood.Follow-up is carried out in the orthopedic consultation for 25 years, reaching the main conclusion that the development of this entity affects little the psychosocial development of the patients.

A new principle of origin and the nature of the action of gravity forces are proposed. Forces of universal attraction have plane-symmetrical directions. On this basis, it becomes possible to reconsider certain regularities in natural science. The new principle of gravitation will allow to explain physical paradoxes, to improve methods of scientific research and some technological processes.

One of the most important Saints of the Eastern Orthodox Church is Saint Spyridon, Bishop of Tremithus of Cyprus, patron saint of Corfu

In this Brazilian breast cancer (BC) case report, we described a pregnant woman diagnosed with BC during the beginning of COVID-19 pandemic. The uniqueness of the case reported is related not only to the particularly fast-growing patient’s situation but also to consider the consequences caused by the pandemic context. The COVID-19 pandemic worsened some difficulties in BC assessment and treatment that we already had previously in Brazil,