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Signet-ring cell carcinoma (SRCC) is defined as a poor prognosis carcinoma and it is not common. Despite the advancement of the technology, origins of about 3%–5% of metastatic tumors remain unknown. Furthermore, metastatic SRCC of unknown primary origin is very rare.

The coronavirus pandemic hit the world unexpectedly, and to respond swiftly to it, lockdown and social distancing measures had to be implemented to combat its spread

1.1. Introduction: Multi-system inflammatory syndrome in adults (MIS-A) is gaining recognition among adult physicians. MIS-A is a rare but important syndrome that can be difficult to distinguish from severe COVID-19. MIS- A can occur following vaccination for SARS-CoV-2 is not reported till date

Major vessel invasion in patients with hepatocellular carcinoma (HCC) receiving living donor liver transplantation (LDLT) is one of the major factors for HCC recurrence. Malignant portal vein thrombosis (MPVT) is an absolute contraindication for liver transplantation (LT).

Coronavirus disease 2019 (Covid-19) is a recent worldwide pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In critical cases it causes acute lung injury (ALI) due to severe acute respiratory distress syndrome (ARDS). I

A 29-year-old woman underwent electrophysiological study for paroxysmal wide-QRS tachycardia with a left bundle branch block (LBBB) aspect (Image A).

1.1. Objective: To contribute to the increased understanding of the clinical features of neuroendocrine carcinoma of the gallbladder revealed by a dermatomyositis

1.1. Background: Extraskeletal mesenchymal chondrosarcoma (EMCS) is an extremely rare malignant tumor arising from soft tissues. It commonly occurs in the lower limbs, orbital cavity, and the central nervous system. Moreover, it is extremely rare for it to develop from a retroperitoneal location. In fact, there is no case about primary retroperitoneal ESMC involving the

1.1. Purpose Encysted adiponecrosis is a benign subcutaneous lesion characterized histologically by encapsulated fat necrosis. Our purpose was to present and discuss an atypical case of adiponecrosis revealed by a chronic hard mass of soft tissue becoming painful, associated with an erythematous skin nodule of undetermined origin

The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1]. Inflammasomes are essential components in innate immunity.