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December 31, 2025


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Integration of AI-Driven ǪSAR Modelling and Organ-on-Chip Technology in Ophthalmic Medicine

Integration of AI-Driven ǪSAR Modelling and Organ-on-Chip Technology in Ophthalmic Medicine

1. Abstract
AI-driven pharmacology in ophthalmology addresses critical challenges in drug discovery for ocular diseases like age-related macular degeneration (AMD) and diabetic retinopathy, where physiological barriers and complex biomarkers hinder tradition- al methods. This review outlines AI’s role in accelerating tar- get identification, lead optimization, and clinical translation to enhance precision medicine and reduce development timelines.

A Complex Autoimmune Case Complicated by Cat Scratch Disease

A Complex Autoimmune Case Complicated by Cat Scratch Disease

1. Abstract
A 30-year-old female patient with a complex medical history, in cluding autoimmune hemolytic anemia, systemic lupus erythematosus (SLE), and hyperthyroidism, has experienced recurrent blood cell decreases over the past 17 years. Recently, she was admitted to the hospital due to a 6-day history of fever, which was slightly alleviated by ibuprofen, but the fever recurred in termittently.

ANCA-Associated Vasculitis Masquerading as Refractory Pneumonia: A Diagnostic Challenge and Lessons Learned

ANCA-Associated Vasculitis Masquerading as Refractory Pneumonia: A Diagnostic Challenge and Lessons Learned

1. Abstract
We present the case of a 66-year-old woman hospitalized for a 7-day history of cough, pro-ductile sputum, chills, and fever, initially managed as community-acquired pneumonia.

Circulating Protein Biomarkers in Breast Cancer: Clinical Significance and Integration  with Molecular Signature

Circulating Protein Biomarkers in Breast Cancer: Clinical Significance and Integration with Molecular Signature

1. Abstract
Breast cancer is biologically heterogeneous; the best way to manage the disease is to have biomarkers that represent the fixed molecular phenotype of the tumor in addition to a dynamic.

Intravenous Recombinant Tissue Plasminogen Activator (Rt-PA) Induced Life-Threatening  Angioedema

Intravenous Recombinant Tissue Plasminogen Activator (Rt-PA) Induced Life-Threatening Angioedema

1. Abstract
An 85-year-old woman with a prior cerebrovascular accident presented with sudden right-sided weakness and aphasia (NI HSS 15). She received intravenous recombinant tissue plasminogen activator (rt-PA) followed by successful mechani.

Invasive Klebsiella Pneumoniae Liver Abscess Syndrome Accompanied by Seminal  Vesiculitis and Prostate Abscess in a Non-Diabetic Patient

Invasive Klebsiella Pneumoniae Liver Abscess Syndrome Accompanied by Seminal Vesiculitis and Prostate Abscess in a Non-Diabetic Patient

1. Abstract
1.1. Background
Seminal vesiculitis, Acute prostatitis or Prostate abscess is usually the complication of urinary tract infection. Simultaneous involvement of seminal vesicle, prostate, and liver secondary to Klebsiella pneumoniae is rare and has rarely been reported in the past as per the Pub Med search

Mycotic Posterior Tibial Artery Aneurysm in a Patient with Diabetes: A Case Report

Mycotic Posterior Tibial Artery Aneurysm in a Patient with Diabetes: A Case Report

1. Abstract
We report the case of a 66-year-old Caucasian man with type 2 diabetes presented with right foot swelling and redness. He was initially managed with intravenous antibiotics for presumed cellulitis; however, there was no clinical improvement.

Expanding the Role of iTind®: First Clinical Experience in Treating Bladder Neck  Contracture Following TURP

Expanding the Role of iTind®: First Clinical Experience in Treating Bladder Neck Contracture Following TURP

1. Abstract
1.1. Background
To present the first documented cases of using the iTind® device as a novel, minimally invasive treatment for recurrent bladder neck contracture (BNC) following transurethral resection of the prostate (TURP), and to assess its feasibility, safety, and early outcomes.

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