1. Abstract
The heterogeneous nature of late-life depression (LLD) necessitates a departure from the traditional “trial-and-error” prescribing model toward a precision-based framework.

1. Abstract
1.1. Objective: Systemic corticosteroids administered during induction of anesthesia are an effective adjunct to control postoperative pain and opioid consumption after several types of surgery. The role of corticosteroids in pain control after thoracic.

1.1 Background
Mesh reinforcement can be used as an adjunct in giant paraoesophagal hernias repairs. The use of synthetic mesh is
associated with significant morbidity whereas biologic mesh is associated with higher rates of recurrence. We aim to assess the safety and effectiveness of biosynthetic absorbable PhasixTM non-ST mesh in the repair of giant paraoesophageal hernias.

1. Abstract
Cerebrotendinous xanthomatosis (CTX) typically presents with infantile diarrhea, juvenile cataracts, and tendon xanthomas. We report a diagnostically challenging case of late-onset CTX in a 48-year-old male presenting with isolated progressive

1. Abstract
Non-melanoma skin cancers commonly affect the lower extremities and scalp, where Mohs micrographic surgery (MMS) often leaves wounds with complex healing challenges due to limited vascularity, thin skin, and patient comorbidities.

1. Abstract
1.1. Background
Pyoderma gangrenosum (PG) is an autoinflammatory phenomenon of the skin, frequently linked with common autoimmune conditions such as rheumatoid arthritis and inflammatory bowel diseases. Postoperative PG (PPG) is an uncommon pathergy variant that often mimics surgical site infection.

1. Abstract
AI-driven pharmacology in ophthalmology addresses critical challenges in drug discovery for ocular diseases like age-related macular degeneration (AMD) and diabetic retinopathy, where physiological barriers and complex biomarkers hinder tradition- al methods. This review outlines AI’s role in accelerating tar- get identification, lead optimization, and clinical translation to enhance precision medicine and reduce development timelines.