+1 7755157689


Iron deposit central large nodule in Alagille syndrome

Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome. In addition, the mutation of Ryanodine receptor 2 (RYR2) gene on chromosome 1 has clarified. Here described is a 7 × 5 cm nodular lesion in segment 4 in a 28-year-old man with ALGS. Through imaging studies and histopathological analysis, the nodule was diagnosed, for the first time, as iron deposit giant nodule. Additionally, a review of previous reports has been made to shed more light on this syndrome.

Case report: a clinical dilemma of diagnosing recurrent incomplete Kawasaki disease

Kawasaki disease (KD) is one of the most common etiologies of acquired heart disease among children worldwide with unknown pathogen. Early recognition and establishing the diagnosis help the clinical pediatrics practitioner delivering intravenous immunoglobulin treatment promptly, which plays the most important part of reducing the risk of developing coronary artery abnormalities.

error: Content is protected !!