Volume 7

1.1. Purpose Encysted adiponecrosis is a benign subcutaneous lesion characterized histologically by encapsulated fat necrosis. Our purpose was to present and discuss an atypical case of adiponecrosis revealed by a chronic hard mass of soft tissue becoming painful, associated with an erythematous skin nodule of undetermined origin

The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1]. Inflammasomes are essential components in innate immunity.

A 57-year-old male was admitted to our Hospital on March 2020 for SARS-Cov2 related interstitial pneumonia. Chest x-ray showed a bilateral interstitial-alveolar pneumonia and Blood gas analysis (BGA) in room air highlighted a severe respiratory failure (pO2 46 mmHg, pH 7.41). D

Pigmentation disorders leading to discoloration or hyperpigmentary of underlying tissue occur widely and gain interest. This study is within the framework of strategies under-developing safe compounds to modulate melanognonesis pathway. Phenolic acids and flavones were tested for their effects, on the viability in murine melanoma (B16-F10) and in primary human keratinocyte (PHK).

1.1. Background: Sinus of Valsalva injury, either due to congenital defect or major traumatic events, was known to be rare.

Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome. In addition, the mutation of Ryanodine receptor 2 (RYR2) gene on chromosome 1 has clarified. Here described is a 7 × 5 cm nodular lesion in segment 4 in a 28-year-old man with ALGS. Through imaging studies and histopathological analysis, the nodule was diagnosed, for the first time, as iron deposit giant nodule. Additionally, a review of previous reports has been made to shed more light on this syndrome.

Kawasaki disease (KD) is one of the most common etiologies of acquired heart disease among children worldwide with unknown pathogen. Early recognition and establishing the diagnosis help the clinical pediatrics practitioner delivering intravenous immunoglobulin treatment promptly, which plays the most important part of reducing the risk of developing coronary artery abnormalities.

Preeclampsia is a condition that affects nearly 8% of pregnant women, usually during the second half of pregnancy (from around 20 weeks) or soon after their baby is delivered. A spontaneous subdural hematoma associated with preeclampsia is extremely rare. The author is reporting in this article the case of a 32-year-old woman with 34 weeks of gestation, who sought treatment for high blood pressure, headache, and proteinuria. Nearly 6 weeks after a cesarean delivery of a stillborn baby, the patient developed headache and palsy of the left VIth cranial nerve. Magnetic resonance imaging revealed a left hemispherical subdural hematoma, with midline deviation.

CleidocranialDysostosis is an autosomal dominant scale dysplasia. We present a case of CleidocranialDysostosis of a female patient with deformities in the development of the osteomyoarticular system due to clavicular agenesis, deficiency in mandibular development and dentition, which was diagnosed very early in childhood.Follow-up is carried out in the orthopedic consultation for 25 years, reaching the main conclusion that the development of this entity affects little the psychosocial development of the patients.

One of the most important Saints of the Eastern Orthodox Church is Saint Spyridon, Bishop of Tremithus of Cyprus, patron saint of Corfu