Whole tumor volume based histogram analysis of ADC for differentitating between WHO grade II and III glioma
The therapeutic approaches and prognosis for gliomas differ con siderably for different tumor grades, it is hence important to accu rately assess glioma grade for treatment planning. In addition to the use of conventional mean value, several studies have reported the use of histogram analysis of ADC in glioma grading [1,2]. How ever only the differentiation between low grade and high grade was concerned, whereas differentiation between grade II and III remains challenging.