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Ankle Malignant Peripheral Nerve Sheath Tumour In A Neurofibromatosis I Patient: A Case Report, Main Differential Diagnosis And Review The Literature

1.1. Introduction: Malignant Peripheral Nerve Sheath Tumors (MPNST) are rare and aggressive sarcomata’s tumors with an overall incidence of 0.001% [1] derived from Schwann cells or pluripotent cells of the neural crest [2-8]. MPNSTs are typically seen in patients aged 20-50 years, and usually in the setting of Neuro Fibromatosis Type 1(NF1) and following radiation therapy [8].

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