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1.1. Background: Amyloidosis are rare diseases related to the pathological aggregation and accumulation of misfolded proteins in the extracellular space generating insoluble deposits. This may occur in almost any tissue and organ, leading to severe structural damages and functional impairments. Oral manifestations are fre quent in systemic amyloidosis and represent 9% of the localized forms.

The role of bone mineral density assessment in health-related quality of life in postmenopausal Han Chinese women prior to clinic diagnosis of osteoporosis

1.1. Purpose: Osteoporosis is a systemic skeletal disease and strongly associated with reduced quality of life (QoL). The aim of the study was to explore BMD that might serve as index of health-related QoL (HRQoL), or the relationship between bone mineral density (BMD) and HRQoL in postmenopausal Han Chi nese women prior to diagnosis of osteoporosis

After sequential therapy with first and third generation EGFR-TKIs, a patient acquired EGFR G719A mutation and responded to afatinib, and then, acquired EGFR T790M mutation when developed resistance to afatinib:a case report

NSCLC patients who had sensitive EGFR mutation had great pos sibility to get benefit from EGFR-TKIs. But this efficacy was re lied on related EGFR mutation, if related EGFR mutation changed, resistance would happened. In our report, we did next generation sequencing(NGS) each time the patient had progression.

Commentary: Defecation delay in patients after lung tumor surgery: a prospective nested case-control study

This is a brief commentary to our article “Defecation delay in pa tients after lung tumor surgery: a prospective nested case-control study” [1]. The author Chen used to be a resident and rotate in different departments of surgery and find that discomfort related to defecation is quite common in patients receiving various opera tion under general anesthesia. Even operations not associated with gastrointestinal tract like thyroidectomy may develop a need for laxatives though patients recovered quickly after the procedure. However, this problem is usually not fully appreciated and just a few studies focused on it.

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