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March 10, 2025


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Volume 1

Recurrent Swelling of the Lower Limbs (Lymphedema) As a Manifestation of the Idiopathic Hypereosinophilic Syndrome

Hypereosinophilic syndrome is an unexplained disorder characterized by prominent blood and bone marrow eosinophilia and tissue eosinophil infiltration. It can cause damage/dysfunction of multiple organs, mainly involving the skin, heart, lungs, gastrointestinal tract and the nervous system.

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Successful Treatment of Systemic Sarcoidosis with Tranilast

Although the effectiveness of tranilast in cutaneous sarcoidosis has been reported, its recorded adoption in systemic sarcoidosis is finite. We report a case of huge subcutaneous sarcoidosis with multiple organ involvement and systemic symptoms relieved quickly after the treatment of tranilast, suggesting that tranilast is expected to become the first-line therapy of sarcoidosis as for its less side effect.

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