Keratin 5 Mutation in a Bulgarian Family with Dowling – Degos Disease – A Case Report and a Review of the Literature
Dowling-Degos Disease (DDD) is a rare reticular pigmentary disorder with an autosomal dominant inheritance. Morbus Galli-Galli is considered to be an acantholytic variant of the disease. Mutations in keratin 5 gene (KRT5) have been found in the majority of DDD patients.