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Throughout the COVID-19 Pandemic, the symptoms of loss of smell and taste have been commonly encountered by healthcare professionals, and in fact, have become an important screening tool. By some estimates, 96% of COVID-19 patients experience these symptoms to various degrees [1]. While the exact mecha nism of cellular events that lead to loss of smell and taste is large ly unknown, research is underway to better understand the pro cess. The senses are usually regained with time but often can take months, and in some instances, be permanent [2]. Nearly one out of ten patients have not fully recovered by two months and treat ment options so far are limited [3]. The use of a low dose of Gab apentin could be a possible treatment for anosmia and ageusia in COVID-19 patients.

Congenital Adrenal Hyperplasia (CAH) is managed with long term corticosteroid and is suggested to higher dose, based on the general sick day principles. I presented a 5-year-old CAH case by pneumonia managed in our pediatrics department. Consider ing stress doses of cortisone in management of CAH patients with COVID19 should be considered.

Lymphangiomas are rare slowly growing benign tumors derived from lymphatic vessels. They occur in various anatomical loca tions of body like head, neck and abdomen. Abdominal cystic Lymphangiomas are rare intra-abdominal masses affecting the in fants and young children, these may be detected incidentally on radiological investigations or present with abdominal distension, vague abdominal pain and life threatening emergencies like bowel obstruction and torsion of cystic masses.

Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with possible widespread distant metastasis. The diag nosis requires thorough clinical, radiological and histopathologic examination. Here, we report a case of a 40-year-old male who presented back pain, paresthesia, dysphagia and swelling around the left mandibular region.

Immunotherapy is an important treatment modality in cancer, but it can also cause adverse reactions, with skin toxicity being the most common. The increasing number of immune checkpoint in hibitors being used in the clinic will inevitably cause an increase in the rate of adverse skin reactions that markedly affect the patient’s quality of life. A 58-year-old patient with intrahepatic cholangio carcinoma developed bullous pemphigoid (BP) nearly a year after using immune checkpoint inhibitors, which is different from what has been reported in the literature within two weeks of treatment. Pathologically, the skin biopsy diagnosis was epidermal hyper plasia and focal sub-epidermal pustule formation, consistent with drug-induced dermatitis.

Patients with Parkinsonism may present acutely to the ED with serious and even life-threatening conditions. Although falls are a common presentation in advanced Parkinsonism, early presen tations with falls should alert the clinician that the patient might have a Parkinson syndrome other than Parkinson’s disease itself, including autonomic neuropathy causing orthostatic hypotension. Patients may present with neuroleptic malignant syndrome, acute psychosis, marked hypokinesis, freezing gait, aspiration pneumo nia, dysphagia, serotonin syndrome, dopamine dysregulation syn drome and intestinal pseudo-obstruction. An inpatient admission is necessary for investigation and observation of these patients.

V-P shunt is the most common surgery done in paediatric hydro cephalus. Though the surgery remains as ‘minor’ in the arena of Neurosurgery, its complication surpass any boundary. Here we discuss a case of shunt complication which had malfunctioning shunt with both end malposition, cranial end occluded by septum and cortex and peritoneal end invading bowel. Surgery was taking a new course for dramatic appearance of COVID 19.

1.1. Background: Thromboembolic events can lead to significant morbidity and mortality. A thrombotic event can occur in Kidney transplant recipients due to several reasons, one of them is the use of sirolimus which has been shown to have thrombogenic poten tial.

1.1. Background: Based on molecular profiling, malignant mel anoma is classified in four different groups. NF1-mutated tumors are a small subgroup occurring with a frequency of 13% of all malignant melanomas, usually harboring a high tumor mutational burden (TMB). Considering TMB as being a prerequisite for the effectiveness of immune checkpoint inhibitor therapy, we were wondering if this rare subtype is associated with a higher response rate to immunotherapy than it is known for the general melanoma population.

Case presenation of a rare clinical manifestation of a relapse of acute lymphoblastic leukemia in a young woman manifested by growing uterus mimicking a myomatous uterus.