December 9, 2022

1.1. Background: Hereditary leiomyomatosis and renal cell car cinoma syndrome (HLRCC) is a rare genetic disease, which is caused by the mutation of fumarate hydratase (FH) gene and in herited by autosomal dominance.

1.1. Introduction: Hysterectomy is the second most common gy necological surgery next to caesarean section. The indications for hysterectomy may vary from one region to another and histomor phological pattern may also vary.

We report a case of infective endocarditis in a patient with congen ital heart valve lesions accompanied by Streptococcus gordonii in fection. A 61-year-old man presented with recurrent fever for four months. Immune system and myelopoietic disorders and tubercu losis were all ruled out as possible causes of the fever. He was diag nosed with subacute Infective endocarditis (IE) after blood culture analysis, which revealed presence of a Gram-negative bacterium – Streptococcus gordonii, combined with his history of precordial valve disease and cardiac ultrasound as well as a four-month histo ry of fever.

COVID 19 mainly affects the respiratory, gastrointestinal and neurological systems but it also involves the oral cavity, olfactory and integumentary system. The oral manifestations of COVID 19 along with inflammatory response of surrounding tissues are due to angiotensin converting enzymes (ACE 2) and Trans membrane serine protease (TMPRSS 2). ACE 2 and TMPRSS 2 play a key role in virus transmission through saliva and shows its expression in the salivary glands, oral mucosal epithelium.

We present a case of a 63-year old man with multiple meningi omas, with no evidence of neurofibromatosis 2