The aim of this study was to investigate the therapeutic effects of vacuum sealing drainage technology combined with home made anal canal treating the deep burn wounds of the buttocks and perineum. From March 2014 to September 2019, after debride ment of buttocks and perineal granulation wounds in 10 cases with large-area deep burns, autologous postage stamp skin was grafted, homemade silicone tube was inserted and fixed in the anus, contin uous catheterization was performed, and the wounds were treated with vacuum sealing drainage technique for 5-7 days. In 9 cases, most of the skin survived, and the wound was healed after chang ing the dressing. Treating deep burn wounds on the buttocks and perineum with VSD technique and anal insertion of homemade canal significantly improved the skin grafting survival effect, re duced the number of operations and complication, and shortened the treatment time.