1.1. Background: Amyloidosis are rare diseases related to the pathological aggregation and accumulation of misfolded proteins in the extracellular space generating insoluble deposits. This may occur in almost any tissue and organ, leading to severe structural damages and functional impairments. Oral manifestations are fre quent in systemic amyloidosis and represent 9% of the localized forms.

NSCLC patients who had sensitive EGFR mutation had great pos sibility to get benefit from EGFR-TKIs. But this efficacy was re lied on related EGFR mutation, if related EGFR mutation changed, resistance would happened. In our report, we did next generation sequencing(NGS) each time the patient had progression.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Its association with Pulmonary Atresia is considered to be the most severe form, the diagnosis of which plays an import ant role in determination of the treatment protocol. In such cases, systemic vascular channels called Major Aortopulmonary Collat eral Arteries (MAPCA’s) develop from aorta and its major branch es to supply and maintain the pulmonary circulation. Such patients commonly undergo a Cardiac CT as an imperative pre-operative investigation for detailed information of these collaterals which helps plan further management.

Patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection mainly present severe pneumonia associ ated with complications related to cytokine storm syndrome. So, it was associated with thrombotic incidents like acute limb ischemia and pulmonary embolism.

1.1. Background: Malignant melanoma is a highly malignant tu mor caused by abnormal proliferation of melanoma cells in the skin and mucous membranes, with a poor prognosis after metasta sis. Skin melanocytes are gradually destroyed in vitiligo patients. There is a certain correlation between these two diseases: In these two conditions, cytotoxic T lymphocytes that target autoantigens shared by normal melanocytes and melanoma cells have been found. Spontaneous melanoma-associated vitiligo was relatively rare before melanoma was diagnosed, and its pathogenesis and prognosis were rarely studied.

1.1. Introduction: Aseptic abscesses (AAs) are neutrophilic in filtrative lesions that often coincide with systemic inflammatory disorders such as inflammatory bowel diseases (IBD). According to recent literature, medical therapies in IBD with AAs include corticosteroid, immunosuppressants and anti-TNFα biologics.