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An Over View of Sterile Filtration Validation: A Key Elements for Sterile Drug Product Manufacturing

1. Abstract
Sterile filter validation is an important process in the pharmaceutical, biotechnology, and healthcare industries to ensure the effectiveness and integrity of sterile filtration systems.

Successful Surgical Retrieval of Fractured Epidural Catheter in Primigravida: A Rare Case Scenario

1. Introduction
Epidural catheter placement is a widely utilized method for administering anesthesia during various surgical procedures. Similar to other medical interventions, epidural insertion carries potential complications, including but not limited to breakage, migration, kinking, abscess formation, radiculopathy, and hematoma development. Nevertheless, the occurrence of a broken epidural catheter is infrequent, with a reported incidence of 0.0015% [1].

Deep Venous Thromboembolism in Gynecological Malignancies

1. Summary
Deep venous thrombosis is a severe complication often following gynecological malignancy. It presents a main reason of post-operative complication, morbidity and mortality in these patients. It is crucial to know risk factors and to diagnose possible early manifestations of the disease in time [1].

Hypoxemia in Polytrauma Patients Requiring Intensive Care Unit: Incidence, Causes, and Impact Outcome

1. Abstract
1.1. Purpose: to study the incidence, the time of development, the etiologies, and the impact outcome of post-traumatic hypoxemia in the intensive care unit.

Neuroprotective Roles of Oleic Acid: An Antioxidant Status and Cerebellar Characterization in Rat Models of Aluminium Chloride-Induced Alzheimer Disease

1. Abstract
1.1. Background: Previous studies have linked Alzheimer’s disease (AD) with cerebellar dysfunction. However, these studies lack substantial cerebellar characterization and features during AD progression.

Emergent Operative Treatment of Aortic Dissection Years after Aortic Valve Balloon Dilatation, Ross Procedure, and Aortic Valve Replacement

1. Abstract
This case report discusses a 38-year-old female with a history of congenital aortic stenosis who underwent the Ross procedure and subsequent aortic valve replacement (AVR) with a biological prosthesis.

Malignant Pheochromocytoma – Disputable Differential Diagnostics and Follow-up Surgical Approach – Case Report

1. Introduction
Malignant pheochromocytomas are rare endocrine tumors that develop within chromaffin tissue. The diagnosis of malignancy is based on neoplastic recurrence or the presence of metastasis in organs
that lack chromaffin tissues [1].

The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call

1. Abstract
The European Medicines Authority (EMA) is a decentralised agency of the European Union (EU) responsible for the scientific evaluation, supervision and safety monitoring of medicines in the EU
and the European economic Area (EEA). On July 11th, 2023, it issued a press release stating that PRAC (The EMA’s safety committee) was reviewing data on the potential risk of suicidal thoughts and thoughts of self-harm with medicines known as GLP-1 receptor agonists, including Ozempic (semaglutide), Saxenda (liraglutide) and Wegovy (semaglutide).

The Biophyisacal Modeling of the Perturbations in the Living System

1. Abstract
A classic example of the symbiosis of structural and functional perturbations is vascular occlusion due to atherosclerosis. Narrowing of the blood vessel is already a serious danger, because very often the formed elements in the blood coagulate as blood clots – larger structural formulas.

We Need to Rehabilitate the Brains of Individuals with Parkinson’s Disease: The Incredible Gains with Transcranial Direct Current Electrostimulation (tDCS)

1. Case Report
Parkinsonian syndromes are determined by the presence of at least two of the four main symptoms: bradykinesia, rigidity, resting tremor and postural instability [2, 18], caused by a reduction in dopamine in the pars Compacta of the substantia nigra [6].

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