1. Abstract
Proteasome maturation protein (POMP), encoded by POMP, is a protein that functions as a chaperone for proteosome maturation. Pathogenic variants in POMP, are associated with the Proteasome- Associated-Autoinflammatory Syndrome (PRAAS), Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK) syndrome, POMP-related autoinflammation and immune dysregulation disease (PRAID), and chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE).

1. Abstract
1.1. Purpose: Surgery is necessary for the treatment of an anal fistula. However, excision of some sphincter muscle would compromise sphincter integrity or function, which is the cause of a reduced success rate in the long term. In order to develop an appropriate surgical plan, a mathematical model that describes the relationship between the internal pressure of the anal canal and the structure of anal sphincters was established in this study.

1. Abstract
Children Born in 2001 Grew to 1 Year Old (On Birth-Day) in 2002, 6 Years Old in 2007, —, 19 Years Old in 2020. They Didn’t Grow Instantly To 19 Years Old In 2002. Growth In Stature Is Longitudinal And Not Cross-Sectional In Nature.

1. Abstract
In literature, very few cases of tuberculosis of the penis have been reported. We hereby present a case report. A 42-year-old man admitted to hospital with a chief complaint of a small, ulcerative growth over glans penis.

1. Abstract
Metabolic acidosis is a condition of excessive blood acidity characterized by an inappropriately low level of bicarbonate in the blood. A person with mild metabolic acidosis may not have symptoms, but usually has nausea, vomiting and fatigue. Breathing becomes deeper and slightly faster, but most people don’t even notice it.

1. Abstract
Objective: To summarize the clinical efficacy of spinal endoscopic surgery in a patient with tophi in the lumbar spinal canal admitted to our hospital. Methods: This patient complained of low back and leg pain for 2 years, which was aggravated for 10 days. After admission, a routine examination was made to formulate a diagnosis and treatment plan, and endoscopic spinal canal debridement was performed.

1. Abstract
1.1. Background Objective: to investigate the clinical character- istics of nine glycolipid antibody-positive patients.

1. Abstract
Background of this study is to analyze different kind of challenges are facing during stability studies of the product. Significance of this study is whether the primary Medical Packaging devices are compatible with the product or not. Basic methodology is used wide ranges of Analytical testing required to avoid market complaint and financial loss of the company.

1. Abstract
Cutaneous Crohn’s disease (CCD) is a rare specific skin manifestation of Crohn’s disease (CD) that can affect the skin of the external genitalia, abdomen, and inguinal regions without involving the affected gastrointestinal tract.

1. Abstract
Cysts of the pineal region are benign, incidental and commonly present on Magnetic Resonance Imaging (MRI) performed for unrelated pathology. When reimaged they are usually stable in size
and imaging characteristics. The case report demonstrates spontaneous remission of a pineal cyst in a patient undergoing MR evaluation for cerebral infarction.