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The Role of Genetic Mutations in Genes RUNX1, RUNX1T1, CBFB & MYH11 on Core Binding Factor Acute Myeloid Leukemia

Acute myeloid leukemia (CBF-AML) is one of the causes of he matopoietic tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body against infection, red blood cells (erythrocytes) ) that carry oxygen and platelets (thrombo cytes) play a role in blood coagulation, in acute myeloid leukemia, the bone marrow produces a large number of abnormal and im mature white blood cells called myeloid blasts.

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