Issue 8

Immunotherapy is an important treatment modality in cancer, but it can also cause adverse reactions, with skin toxicity being the most common. The increasing number of immune checkpoint in hibitors being used in the clinic will inevitably cause an increase in the rate of adverse skin reactions that markedly affect the patient’s quality of life. […]

1.1. Background: Based on molecular profiling, malignant mel anoma is classified in four different groups. NF1-mutated tumors are a small subgroup occurring with a frequency of 13% of all malignant melanomas, usually harboring a high tumor mutational burden (TMB). Considering TMB as being a prerequisite for the effectiveness of immune checkpoint inhibitor therapy, we were

1.1. Background: Thromboembolic events can lead to significant morbidity and mortality. A thrombotic event can occur in Kidney transplant recipients due to several reasons, one of them is the use of sirolimus which has been shown to have thrombogenic poten tial.