Red Blood Cell Transfusions May Have the Stongest Analgesic Effect during Acute Painful Crises in Sickle Cell Diseases
1. Abstract 1.1. Background: The hardened red blood cells (RBC)-induced capillary endothelial damage, inflammation, edema, and fibrosis are initiated at birth, and terminate with disseminated tissue hypoxia, acute painful crises, multiorgan failures, and sudden death even at childhood in the sickle cell diseases (SCD).