Author name: admin

Cytokine storm syndrome (CSS) is a critical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure. At the end of 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and rapidly developed into a global pandemic. There is a dramatic increase of inflammatory cytokines in patients with COVID-19, suggesting the existence of cytokine storm in some critical illness patients. Here, we summarize the pathogenesis, clinical manifestation of CSS, and highlight the current understanding about the recognition and diagnosis of CSS in COVID-19.

Programmed cell death protein 1 (PD1)/programmed death ligand 1 (PD-L1) blockades provide an effective and safe therapeutic option in the field of refractory cancer therapy. However, not more than 30% response rate of most cancers seriously impedes their therapeutic efficacy. Previous investigations have proved the effectiveness of combining chemotherapy with immunotherapy for unsatisfactory response to anti-PD1

1.1 Background: Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Furthermore, it is becoming increasingly popular in the western countries.

Benzodiazepines use in the elderly are associated with morbidity including increased falls, fractures, and mortality. The common reason for re-prescribing benzodiazepine by physicians is dependency

1.1. Background: Hepatic artery aneurysm is a rare clinical entity amongst children accounting for 20 % of all the splanchnic artery aneurysms, and if neglected could lead to catastrophic events

1.1. Purpose: Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. However, the associations between excess weight and prognostic factors for thyroid cancer are uncertain.

We report a case of slowly progressive Becker’s muscular dystrophy in a 52-year-old man who required cardiac transplantation for intractable congestive heart failure. A referral was made concerning prognosis of his muscular dystrophy in the multidisciplinary approach to transplant.

Acute stroke in bacterial meningitis in children contributes to high morbidity and mortality. The incidence of stroke in pediatric meningitis is varied, with reports between 8-42%, and associated mortality as high as 25%.

1.1. Introduction: We herein present a case of methotrexate-associated lymphoproliferative disorder (MTX-LPD) with a diagnosis of an 8-mm thyroid tumor of class III cytology that grew three times larger during 2 years 8 months before resection.

1.1. Background: With the intention to quantify the importance of a medical journal, the impact factor (IF) was introduced. It has become a de facto fictive rating instrument of the importance of medical journals. Also, it is often used to asses the value of the individual publications within the specific journal. The aim of the present study was to analyze publication trends over 20 years in five high-ranked anesthesiology journals.