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1.1. Background: Malignant melanoma is a highly malignant tu mor caused by abnormal proliferation of melanoma cells in the skin and mucous membranes, with a poor prognosis after metasta sis. Skin melanocytes are gradually destroyed in vitiligo patients. There is a certain correlation between these two diseases: In these two conditions, cytotoxic T lymphocytes that target autoantigens shared by normal melanocytes and melanoma cells have been found. Spontaneous melanoma-associated vitiligo was relatively rare before melanoma was diagnosed, and its pathogenesis and prognosis were rarely studied.

1.1. Introduction: Aseptic abscesses (AAs) are neutrophilic in filtrative lesions that often coincide with systemic inflammatory disorders such as inflammatory bowel diseases (IBD). According to recent literature, medical therapies in IBD with AAs include corticosteroid, immunosuppressants and anti-TNFα biologics.

Obesity is a disease characterized by the abnormal accumulation of body fat. It is estimated that there are 650 000 000 obese adults. Its incidence has increased in recent years, contributing to the de crease in the average life expectancy of up to 12 years and with a worsening in the quality of life of the obese, mainly due to the association with systemic diseases. This study was to verify the effect of Bariatric surgery on the quality of life of obese patients with a BMI greater than or equal to 35 kg/m2 through verifica tion of the perception of these operated patients about changes in quality of life.

1.1. Background: Gallbladder stones is one of the most common disease of the digestive system. Giant gallbladder stone is rare and subject to technical difficulties in laparoscopic cholecystectomy with high rate of conversion to open cholecystectomy

Thyroid-associated ophthalmopathy (TAO) is an autoimmune dis ease associated with thyroid-related posterior ocular and perimeter orbital tissue invasive lesions, with a very high incidence of adult orbital disease, with a male and female proportion of about 3:16. Patients with mild diseases have little impact on life, and moderate and severe cases will even lose vision and even blindness, which brings great inconvenience to life. Therefore, effective treatment is very necessary.

Chronic subdural hematoma generally occurs in elderly patients. Anti-coagulation is also a frequent risk factor for this disease. The objective of this report was to present the rare case of a right hemi spheric subdural hematoma associated with a COVID-19 lung in fection in an 81years old female patient, both diagnoses confirmed with imaging and biological work-up. On admission, she present ed with an altered general state as well altered state of conscious ness, chest pain and left side motor deficit. The management of the subdural hematoma was surgical while the COVID-19 pneu monia was managed using a medical protocol which included cu rative anticoagulation. The post-operative course was marked by re-bleeding of the subdural hematoma.

A 39-year-old man presented to the emergency room with com plaints of fever, shortness of breath and pronounced dry cough for 1 week. On physical examination, his respiratory rate was 28 breaths/min and his oxygen saturation was 87 % on room air, im proving to 96% on 8L/min oxygen via a non-rebreathing mask. He also had palpable crepitus around the neck and the upper thoracic region. Reverse transcription (RT)-PCR analysis of COVID-19 was positive. Chest computed tomography showed typical find ings of COVID-19 pneumonia, affecting 60% of lung parenchym

1.1. Background: True iliac aneurysms development is a major sign of aneurysm disease progression after open repair for Abdom inal Aortic Aneurysm (AAA). We present our experience in en dovascular repair of true iliac aneurysm after open reconstruction for ruptured AAA with commercially available stent graft devices.

Indirect inguinal hernia of the canal of Nuck containing the pelvic organs such as ovary is a rare entity among females of pediatric age group which presents as swelling of labia majora. It is caused by congenitally failed closure of the processus vaginalis in female resulting in the formation of a potential space which is named as “canal of Nuck” through which pelvic organs herniate. Literature review showed that in female infants around 15-20% of the cases, this canal of Nuck hernia contains ovary with or without herniation of fallopian tube.

Prolapsed colostomy is a well-known complication, occurring with transverse colostomies more frequently than other types of colostomies. It is usually managed conservatively when it is un complicated; however, surgical revision is advisable in complicat ed cases if the reversal of stoma cannot be done. We present a novel approach of local revision of transverse loop colostomy in a patient with synchronous splenic flexure and rectal adenocarcino mas, who was referred to our center after undergoing a Hartmann’s procedure for splenic flexure tumor, and still pending surgical op eration for rectal tumor. Here we describe a simple, reproducible procedure that does not involve entrance to the abdominal cavi ty, using readily available instruments in any secondary hospital. Post-operative follow-ups showed no recurrence, acute or chronic complications.