Silencing HO-1 Inhibits Oxidative Stress, Restores Expression of Members of Iron Metabolism, and Attenuates the in Vitro Carcinogenic Activity of PCBs
1. Abstract HMOX1 (HO-1) might be involved in the mechanism of polychlorinated biphenyl (PCB)-induced tumorigenic effects through influences on iron-metabolism factors. This work aimed to investigate the in-vitro effect of HO-1 silence on the PCBs treated BC cells. The breast cancer cell lines MCF-7 and MDA-MB-231 were used for analysis of in-vitro functions.