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Sequential Bispecific Antibodies in Functional and Clinical High Risk Multiple Myeloma, Manifesting with Extramedullary Disease at Relapse: A Case Report

1. Case Report Despite recent advances in the treatment of multiple myeloma (MM), the disease remains incurable. Triple class refractory (TCR) patients, defined as refractory to a proteasome inhibitor (PI), immunomodulatory agent (IMiD), and anti-CD38 monoclonal antibody have demonstrated to have especially poor outcomes with a median overall survival of less than 1 year [1-3].

Notes on Diabetes

1. Introduction Diabetes Mellitus (DM) comprises a heterogeneous group of systemic, chronic diseases of unknown cause, with variable degrees of hereditary predisposition and the participation of various environmental factors that affect the intermediate metabolism of carbohydrates, proteins and fats that They are pathophysiologically associated with a deficiency in the quantity, timing of secretion and/or action […]

Antibiotic Prescription and Consumption in Brazil: Impact in the Global Health

1. Abstract Despite the antibiotic sale prohibition without medical prescription since 2010, excessive and often inappropriate antibiotic prescription and self-medication, are still common practices in Brazil. Indiscriminate antibiotic use is directly involved with the dissemination of resistant bacteria causing serious infections increasingly difficult to treat.

Silencing HO-1 Inhibits Oxidative Stress, Restores Expression of Members of Iron Metabolism, and Attenuates the in Vitro Carcinogenic Activity of PCBs

1. Abstract HMOX1 (HO-1) might be involved in the mechanism of polychlorinated biphenyl (PCB)-induced tumorigenic effects through influences on iron-metabolism factors. This work aimed to investigate the in-vitro effect of HO-1 silence on the PCBs treated BC cells. The breast cancer cell lines MCF-7 and MDA-MB-231 were used for analysis of in-vitro functions.

Prednisone and Tranexamic Acid Oral Treatment in Chronic Subdural Hematoma: Case Series

1. Abstract 1.1. Background: During the Covid era, the avoidance of suggest to come to the hospital for patient with simptoms and pathology which can be treated conservatively, have been a diffused habit. Chronic subdural hematoma is a well known neurosurgical pathology, which can be treated by surgical intervention or conservative treatment, and the choice […]

Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of P53 In Selected Cases

1. Abstract Oral squamous cell carcinoma (OSCC) represents 3% of all malignant neoplasms. Considering the observed regional occurrence of OSCC, the aim of this study was to analyze the incidence and clinical characteristics of patients with primary carcinoma of the oral cavity diagnosed in the province of Tucumán, in the Northwestern of Argentina, where habits […]

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