Immediate Resolution of Non-Withdrawel Delirium Through Daridorexant: A Report of Two Cases

1. Abstract We report here two cases of older women, 84 and 97 years old, who were admitted to our department for conservative treatment after a fall. Both women developed delirium in the course of the inpatient stay. After administration of 50mg Daridorexant, deliri- um was completely dissolved the next morning. Delirium did not recur even after discontinuation of medication. To the best of our knowledge, this is the first report of the efficacy of Daridorexant in the treatment of delirium. As part of an ongoing study in our department, these observations will be further objectified.

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