March 1, 2023

In recent years, people’s exposure to pulsed radiofrequency (RF) or microwave radiation from wireless technologies has exploded, mainly due to the roll-out of 5G. In addition to more base sta tions, millions of so-called smart water and electricity meters are being installed. This technology is forced upon people near or in their own homes, despite a complete lack of research showing that 5G and wireless water and electricity meters are not harmful to human health. At the same time, the first two studies to date on the effects of 5G have shown that 5G base stations cause adverse health effects in humans and that radiation similar to 5G damages neurons in the brain in animal experiments.

Paediatric inflammatory bowel disease (IBD) is a chronic disease with a multifactorial etiology. The role of nucleotide-binding oli gomerization domain (NOD)-like receptor protein 12 (NLRP12) in IBD pathogenesis and the clinical relevance of variants of NLRP12 in IBD disease course have not yet been clarified. We report a child with IBD and a wide range of extra-intestinal symptoms in whom many years after IBD onset a novel variant-of-unknown clinical significance (VUS) in the NLRP12-gene was found. Targeted ad justment of therapy improved the clinical course of the extra-in testinal manifestations, suggesting a causative relation with this VUS. We provide an overview of the available literature on the role of NLRP12 in the pathogenesis of IBD.