February 3, 2022

1.1. Background: Based on molecular profiling, malignant mel anoma is classified in four different groups. NF1-mutated tumors are a small subgroup occurring with a frequency of 13% of all malignant melanomas, usually harboring a high tumor mutational burden (TMB). Considering TMB as being a prerequisite for the effectiveness of immune checkpoint inhibitor therapy, we were wondering if this rare subtype is associated with a higher response rate to immunotherapy than it is known for the general melanoma population.

1.1. Background: Thromboembolic events can lead to significant morbidity and mortality. A thrombotic event can occur in Kidney transplant recipients due to several reasons, one of them is the use of sirolimus which has been shown to have thrombogenic poten tial.