The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1]. Inflammasomes are essential components in innate immunity.
A 57-year-old male was admitted to our Hospital on March 2020 for SARS-Cov2 related interstitial pneumonia. Chest x-ray showed a bilateral interstitial-alveolar pneumonia and Blood gas analysis (BGA) in room air highlighted a severe respiratory failure (pO2 46 mmHg, pH 7.41). D
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