Methotrexate (MTX) is a folate inhibitor drug used to treat rheu-
matologic diseases and, at higher doses, as antineoplastic medica-
tion.

Numerous studies have explored the possibility of an association
between breast implants and systemic symptoms potentially linked
to exposure to silicone. Some studies show no direct association
whereas others provide insufficient scientific evidence to prove or
disprove an association.

1. Abstract Respiratory infection due to COVID-19 has been associated with thrombotic events such as deep vein thrombosis, pulmonary embolism, and, to a lesser extent, arterial thrombosis. Cases of acute aortic occlusion in COVID-19 patients have been previously described in the literature. A

1. Introduction
Cardiogenic shock (CS) is a devastating syndrome with heterogenous etiology ranging from intrinsic acute or chronic myocardial damage to pericardial diseases, arrhythmias or conduction abnormalities and valvular heart disease [1].

1. Introduction
Cardiogenic shock (CS) is a devastating syndrome with heterogenous etiology ranging from intrinsic acute or chronic myocardial damage to pericardial diseases, arrhythmias or conduction abnormalities and valvular heart disease [1].

1. Introduction
A human is not only a purely biological construct but also containsa substrate of biochemical, bioelectronic, computer and cybernetic
processes, which are responsible for shaping the psychobiological processes of a human.

1. Abstract
Breast cancer is the most prevalent cancer among women globally. Within breast cancer, the HR+/HER2+ subtype is particularly
notable among luminal subtypes, as it shows resistance to both endocrine and anti-HER2 therapies. This is especially true for cases
with local visceral metastasis, where the necessity of adding local therapy.

1. Abstract
1.1. Introduction
Primary Obturator Nerve pathologies are extremely rare; however, iatrogenic injury might be more common or under reported due to many pelvic lymphadenectomies performed in urology. Our objective is to describe this uncommon pathology laparoscopic resected and review the literature about reports of obturator nerve iatrogenic injury.

1. Abstract
1.1. Introduction
Bone marrow fibrosis is seen in a number of conditions like hematological malignancies, non malignant conditions like infections,
autoimmune disorders, drugs, end stage renal disease etc.

1. Abstract
1.1. Objective
This study aims to investigate the clinical characteristics, timing of intervention, diagnostic and treatment options, and prognostic factors in patients with iTTP