1. Summary
This article describes application of different trends of surgical reconstruction of breast surgical removal of cancer lesion, which is needed for women after this type of surgery from psychological reasons to minding their appearance and increasing their confidence.

1. Abstract
1.1. Objectives: The main electrophysiological manifestation of autoimmune paranodopathy with anti-contactin-associated protein 1 (Caspr1) positive reported previously was demyelination, with or without axonal involvement. Here, we reported a patient with anti-Caspr1 IgG1 positive who had severe axonal involvement accompanied less evidence of demyelination.

1. Abstract
Neuroendocrine carcinoma of the gallbladder (NECGB) is a rare and aggressive tumor with a poor prognosis. The clinical presenta- tion is non- specific, but it occurs more frequently in women with gallstones. Histological and immunohistochemical confirmation is required to establish a diagnosis.

1. Abstract
Epidermolysis bullosa (EB) is a mucocutaneous genetic disease characterized by fragility of the dermoepidermal junction. Laryngeal lesions frequently occur in junctional epidermolysis bullosa (JEB), a subtype of EB.

1. Abstract
1.1. Introduction: Patients with Alirocumab resistance has not been confirmed in the current literature.

1. Part 2
As mentioned before AFP plays crucial role in childhood cancers and genetic-related children’s chronic diseases

1. Introduction
A vagina fistula is a tunnel-like opening that develops in the wall of the vaginal. The vagina is the muscular tube between vulva and cervix, the mouth of the uterus.

1. Abstract
Pelargonium graveolens is an aromatic and medicinal plant, belonging to the Geraniaceae family that grows in temperate areas of the world, which characterized by its therapeutic proprieties. It is widely known as one of the medicinal herbs with the highest antioxidant activity.

Editorial
Extracorporeal life support (ECLS) is used worldwide as rescue therapy to manage severe COVID-19-related acute respiratory distress syndrome (ARDS). In patients supported with venovenous extracorporeal membrane oxygenation (VV ECMO) for COVID- 19-related ARDS, the overall mortality rate is approximately 39%, and the mean ECMO duration (approximately 15 days) seems to be longer than that of other etiologies [1]. Only a few cases of successful native lung recovery have been reported after prolonged VV ECMO (>28 days) [2,3].

1. Summary
Alpha-fetoprotein [AFP] is a protein normal made by the yolk sac, intestines and liver of a developing foetus. AFP levels go down soon after birth, so healthy children and adults usually have very little AFP in their blood. A higher level of AFP in the blood may also mean that there is something wrong in the liver. In this article we will point out problems clinicians may face while getting results of AFP levels out of physiological range in pregnancy (Figure 1) and levels out of range in different organ systems.