Corneal Perforation in Mooren Ulcer
1. Clinical Images A 57-year-old woman presented to ophthalmologist with pain, redness with diminution of vision, of her left eye over a period of last 5 months. On examination, the visual acuity was 20/20 in the right eye and counting fingers in the left eye.
Production of Microcrystalline Cellulose from Fibrous Maize Stem: Re-Engineering Food By-Products for Pharmaceutical Use
1. Abstract Microcrystalline cellulose (MCC) has become one of the major pharmaceutical excipients in high demand in the world today. The constant use of wood to produce microcrystalline cellulose may lead to the danger of deforestation.
Expression of Catenin Delta 1 (CTNND1) in Pancreatic Cancer and Its Influence on Tumor Cell Biological Behavior
1.1. Objective: To explore the role of Catenin Delta 1 (CTNND1) in pancreatic cancer and its possible mechanism. 1.2. Methods: We selected CTNND1 as the research target us ing gene expression profile databases and bioinformatics analy sis methods. CTNND1 expression in the pancreatic cancer cell line PANC-1 was suppressed by siRNA technology, and various cell biological experiments were used to evaluate the impact of CTNND1 on cell proliferation, migration, invasion, apoptosis, and cell cycle. Meanwhile, the protein levels of epithelial-mesenchy mal transition (EMT) related biomarkers were detected to explore whether CTNND1 can regulate EMT in pancreatic cancer cells. 1.3. Results: We found that CTNND1 expression in pancreatic cancer cells was significantly increased. Knockdown of CTNND1 significantly reduced the proliferation, migration, and invasion ability of PANC-1 cells, increased the apoptosis rate, and inhib ited the cell cycle progression. In addition, CTNND1 knockdown could regulate EMT in pancreatic cancer cells. 1.4. Conclusion: Our research results reveal the important role of CTNND1 in pancreatic cancer and propose its possible mech anism of action. These findings provide a new theoretical basis for the treatment of pancreatic cancer, and CTNND1 may become a new target for pancreatic cancer treatment. However, more in depth research is still needed to clarify the specific role of CTN ND1 in pancreatic cancer and its detailed molecular mechanism.
Viral load and antibody responses in an asymptomatic/minimally symptomatic SARS-CoV2 positive cohort in Sri Lanka
Asymptomatic patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are silent carriers of the disease. We aimed to characterize their dynamics of disease occurrence, viral shedding and antibody responses using a cohort of asymptomatic/ minimally symptomatic patients from Sri Lanka during the first wave of COVID-19.
FOLFOX Combined with Mithramycin-A Has A Cytotoxic Effect On The Primary Colorectal Cancer Stem Cells
1.1. Objectives: To screen out sensitive chemotherapy regimens for cancer stem cells (CSCs) from colorectal cancer (CRC) pa tients in northeast Sichuan of China and provide the basis for “re gional precision” targeted therapy
Structure and development of a clinical decision support system: application in high Digestive Gastroenterology
Clinical decision requires to infer great, diverse and not suitably organized quantity of information and having low time to decide. The therapeutic choice is fundamental to formulate a strategy to avoid complications and to achieve favorable results, being more important in some specialties. In addition, medical decision-mak ers are overloaded with clinical tasks, have an intense work rate and are subject to a great demand, and are prone to greater tiredness.