1. Abstract 1.1. Background: Sickle cell diseases (SCDs) are inborn and catastrophic processes on vascular endothelium, particularly at the capillaries.
A Comparative Study of Fissurectomy Versus Lateral Internal Sphincterotomy in Treatment of Chronic Anal Fissure Regarding Post-Operative Complications
1. Abstract 1.1. Introduction: An anal fissure (fissure-in-Ano) is a small, oval- shaped tear in the skin that lines the opening of the anus which is quite common in the general population. Anal fissures are either acute or chronic. Chronic fissures typically require surgical treatment, despite the emergence of new conservative techniques, such as nitric […]
1. Abstract 1.1. Introduction: Normal morphometric measurements of craniovertebral junction is useful for evaluating abnormalities of the craniovertebral junction which helps in diagnosis of most abnormalities.
1. Abstract Metabolic acidosis is a condition of excessive blood acidity characterized by an inappropriately low level of bicarbonate in the blood. A person with mild metabolic acidosis may not have symptoms, but usually has nausea, vomiting and fatigue. Breathing becomes deeper and slightly faster, but most people don’t even notice it.
1. Abstract 1.1. Introduction Superior/anterior umbilical ectopias with non-disruptive origins are uncommon, and have been minimally investigated. DOI:https://doi.org/10.47829/ACMCR.2023.11602
Mathematical Modeling of Histone Deacetylases to Predict their Response against Belinostat Drug Treatment for Smooth Muscle Cells Proliferation
1. Abstract 1.1. Background: The family of enzymes known as histone deacetylases (HDACs) serves as an objective target for regulating the phenotypic of smooth muscle cells (SMCs) and advanced smooth muscle cells (ASMCs).
Evaluation of Clinical Significance of Vitamin B12 Status in Patients Admitted with Acute Febrile Illness Thrombocytopenia at Tertiary Care Hospital
1. Abstract 1.1. Background: Thrombocytopenia is one of the most important hematological manifestations of many infections which may present with pyrexia. Vitamin B12 deficiency is highly prevalent nutritional deficiency in India and it may also be associated with low levels of platelets. This study was planned to evaluate clinical significance of vitamin B12 status in […]
1. Abstract 1.1. Background: Glucosidase II is an endoplasmic reticulum heterodimer enzyme, a neutral glucosidase, involved in the trading and folding of newly synthesized glycoproteins in the endoplasmic reticulum. The destruction of GANAB leads to the accumulation of misfolded glycoproteins and the induction of unfolded protein responses. GANAB is also a key regulator of glycosylation.
Frequency of pin tract infection among patients with tibia fracture treated with AO external fixator
1.1. Introduction: The management of open tibial fractures re mains a challenge for the orthopedic surgeons as various post-op erative complications are associated with external fixation of tibia fracture. 1.2. Objectives: To determine frequency of pin track infection among patients with tibia fracture treated with AO external fixator. 1.3. Material and Methods: This Descriptive case series study was carried out Department of Orthopedics, Medical Teaching In stitute Lady Reading Hospital from February , 2022 till December, 2022 on 110 Patients, aged 20 to 60 years of either gender with open fracture tibia Gustillo-Anderson type II or type IIIA were enrolled using non-probability consecutive sampling technique. All patients with tibia fracture underwent AO external fixation and reduction. Frequency of pin tract infection was noted. Data was entered and analyzed using SPSS 22. 1.4. Results: In our study 110 patients were enrolled with mean age of 36.7±11.5 years. There were 56.4% males and 43.6% fe male patients. Mean duration of injury was 14.6±7.6 hours. Hy pertension was present in 30.9% patients. Diabetes was present in 16.4% patients. Smoking was present in 36.4% patients. Obesity was present in 41.6% patients. Pin tract infection was present in 16.4% patients. 1.5. Conclusion: Our study concludes that the incidence of pin tract infection is high.
Investigation of Methylation Levels in OPRK1 Gene Promoter among Smokers and Opium-Addicts underwent Methadone Maintenance Treatment
1.1. Background: Previous studies reported the association of the OPRK1 gene with illicit substances, nicotine, and alcohol. The present study aimed to look at the methylation levels of OPRK1 gene promoter among smokers and addicts who underwent metha done maintenance treatment (MMT). 1.2. Methods: DNAs were extracted from the whole blood of all male samples including 30 smokers, 30 opium-addicted individu als undergoing methadone treatment, and 30 healthy people, and they were treated with a sodium bisulfite kit. The studied region included 53 CpG dinucleotides investigated by sequencing tech nique. 1.3. Results: Results of methylation levels in addicted individuals who underwent MMT compared with healthy people showed no difference. Also, there was no change in any CpG sites of OPRK1 gene promoter in both smokers and compared healthy controls. There was a significant difference in the mean age between opi um-dependent people and healthy controls (P=0.017). According to the findings of the statistical analysis, resident situation and li bido dysfunction were associated with methadone dose (P=0.032 and P=0.003, respectively). 1.4. Conclusion: Altogether, the study of methylation levels at OPRK1 gene promoter was not significant among smokers and in dividuals who underwent MMT compared to the healthy controls; additionally, methadone dosage had significant associations with demographical statuses in the MMT group.