Volume 15 Archives - Page 3 of 4 - Annals of Clinical and Medical Case Reports®

Integration of AI-Driven ǪSAR Modelling and Organ-on-Chip Technology in Ophthalmic Medicine

Leave a Comment / Volume 15 / Cuneyt Karaarslan, MD

1. Abstract AI-driven pharmacology in ophthalmology addresses critical challenges in drug discovery for ocular diseases like age-related macular degeneration (AMD) and diabetic retinopathy, where physiological barriers and complex biomarkers hinder tradition- al methods. This review outlines AI’s role in accelerating tar- get identification, lead optimization, and clinical translation to enhance precision medicine and reduce development […]

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A Complex Autoimmune Case Complicated by Cat Scratch Disease

Leave a Comment / Volume 15 / Jian Liu, MD

1. Abstract A 30-year-old female patient with a complex medical history, in cluding autoimmune hemolytic anemia, systemic lupus erythematosus (SLE), and hyperthyroidism, has experienced recurrent blood cell decreases over the past 17 years. Recently, she was admitted to the hospital due to a 6-day history of fever, which was slightly alleviated by ibuprofen, but the

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Circulating Protein Biomarkers in Breast Cancer: Clinical Significance and Integration with Molecular Signature

Leave a Comment / Volume 15 / Faris Q.B. Alenzi, PhD,

1. Abstract Breast cancer is biologically heterogeneous; the best way to manage the disease is to have biomarkers that represent the fixed molecular phenotype of the tumor in addition to a dynamic.

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Invasive Klebsiella Pneumoniae Liver Abscess Syndrome Accompanied by Seminal Vesiculitis and Prostate Abscess in a Non-Diabetic Patient

Leave a Comment / Volume 15 / Inder Preet Singh Bhatia, MD

1. Abstract 1.1. Background Seminal vesiculitis, Acute prostatitis or Prostate abscess is usually the complication of urinary tract infection. Simultaneous involvement of seminal vesicle, prostate, and liver secondary to Klebsiella pneumoniae is rare and has rarely been reported in the past as per the Pub Med search

Invasive Klebsiella Pneumoniae Liver Abscess Syndrome Accompanied by Seminal Vesiculitis and Prostate Abscess in a Non-Diabetic Patient Read More »

Horizontal and Vertical Ridge Augmentation Utilize Allogeneic Bone Block Graft in Anterior and Premolar Area Prior To Implant Placement Follow Up 2 Years

Leave a Comment / Volume 15 / Elsaid Ahmed Elganna, MD

1. Abstract Allografts, derived from donor tissue, are widely utilized in various medical fields, including orthopedics, reconstructive surgery, and organ transplantation.

Horizontal and Vertical Ridge Augmentation Utilize Allogeneic Bone Block Graft in Anterior and Premolar Area Prior To Implant Placement Follow Up 2 Years Read More »

From Malignancy to Sarcoidosis: Two Surprising Cases

Leave a Comment / Volume 15 / Ceren Degirmenci, MD

1. Abstract 1.1. Background Sarcoidosis is a multisystem granulomatous disease of unknown etiology, which can occasionally manifest as sarcoid-like reactions in patients with a history of malignancy. These reactions may pose significant diagnostic challenges.

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Case Report: Pembrolizumab-Induced Epiglottitis in Early Triple Negative Breast Cancer

Leave a Comment / Volume 15 / Ahmed Hadeya, MD

https://doi.org/10.47829/ACMCR.2025.15101 The neoadjuvant use of the immune check point inhibitor (ICI) pembrolizumab has significantly increased the complete pathological response (CPR) rate for early triple negative breast cancer (TNBC). However, pembrolizumab is associated with a variety of immune related adverse events (irAEs).

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Late-onset Cerebrotendinous Xanthomatosis with Mild Symptoms: A Case Report

Leave a Comment / Volume 15 / Pei Shang, MD

1. Abstract Cerebrotendinous xanthomatosis (CTX) typically presents with infantile diarrhea, juvenile cataracts, and tendon xanthomas. We report a diagnostically challenging case of late-onset CTX in a 48-year-old male presenting with isolated progressive dys arthria as the sole predominant neurological feature. Notably,

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Long-Term Treatment With BRAF/MEK Inhibitors for Pleomorphic Xanthoastro- cytoma Grade 3: A Case Report

Leave a Comment / Volume 15 / Ana Misir Krpan, MD, PhD

1. Abstract 1.1. Background Pleomorphic xanthoastrocytoma grade 3 is rare disease classified as a distinct entity in WHO classification 2016. It is usually refractory to a standard therapy for high grade gliomas and has a dismal prognosis.

Long-Term Treatment With BRAF/MEK Inhibitors for Pleomorphic Xanthoastro- cytoma Grade 3: A Case Report Read More »

Pharmacological Awakening: An indispensable tool for Awake Craniotomy: A Case Report

Leave a Comment / Volume 15 / Kunal Kumar Sharma, MD

1. Abstract Awake craniotomy allows safe and effective resection of brain tumours near eloquent areas. However, achieving timely and reliable intraoperative awakening is crucial, particularly when pre-existing pathologies and sedative agents delay emergence.

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Annals of Clinical and Medical Case Reports®

Volume 15