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February 22, 2025


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Volume 14

Increasing Dominance of the Earlier Years of Childhood in Advancing Child Height in Asia, South Korea as Compared to Japan

1. Introduction Children in Northeast Asia grew steadily taller in height through most of the past half century. Reflecting substantially greater economic progress, children in Japan were taller in height than their South Korean peers in the 1950s through 1970s. Children in Korea caught up with Japanese peers in the 1990s and over took Japanese children in mean height by 3-4 cm in the mid-2000s and seem to have ceased growing any taller (Figure 1).

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Periodontal and Oral Status of Patients with Celiac Disease: A Case Report

1. Abstract Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten consumption, leading to small intestinal damage. The immune response often involves IgA antibody production, which can accumulate in gingival tissues. Periodontitis, a complex interplay of plaque and host immune inflammation shares similarities with CD’s inflammatory nature.

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Proposal of a West-High–East-Low Hypothetical Theory for the Longitudinal Distribution of Global Height

1. Abstract In this study, we seek to propose a hypothetical theory of western high-east low and the K&F theory (Kani and Fujii theory), similar to Bergmann’s law of north-high and south-low for height, as laws based on latitude and longitude with regard to the trends in global height distribution. Judging from the changes in height over the 100-year span from 1870 to 1970, a composition was suggested in which, taking the European region as the center, height was clearly higher in the west and lower in the east with eastward movement. In other words, it was speculated that diversity decreased as people moved east, leading to slower economic development, lower wealth, and shorter stature. Therefore, we can hypothesize a west-high, east-low composition in the height distribution over longitude. Here, we propose the K&F theory (Kani and Fujii theory) to explain the hypothetical theory of west-high, east-low.

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Exploring The Relationship between Injury, Addiction, and Physical Activity: A Path to Recovery for Athletes

1. Abstract 1.1. Aims Elite, professional athletes face elevated levels of stress, anxiety, or depression, which sometimes lead to use of illicit substances to mitigate stress by self-medication. This study aimed to highlight the need for developing tailored, exercise mediated approaches to recovery from substance use disorders (SUD) and alcohol use disorders (AUD), offering significant benefits for athlete-specific rehabilitation, and reintegration into their social and professional environment

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A Case Study of a Rare Parameningeal Site as Middle-Ear: Highlighting an Overlooked Oncologic Rarity in the Pediatric Population

1. Abstract 1.1. Background: This article aims to underscore the rarity and complexity of pediatric angiosarcoma through a case study of a rare parameningeal site in the middle ear. Management is challenging due to the tumor’s infiltrative nature, particularly in the head and neck region.

A Case Study of a Rare Parameningeal Site as Middle-Ear: Highlighting an Overlooked Oncologic Rarity in the Pediatric Population Read More »

A Coexistence of Epithelial and Mesenchymal Neoplasm in A Tertiary Health Care Center. Synchronous Tumor in Gastro-Oesphagectomy Specimens- A Retrospective Analysis

1. Abstract We are describing three cases of simultaneous occurrences of an epithelial lesion with a mesenchymal lesion in the gastrointestinal tract. The synchronous occurrences in first case are with oesophageal squamous cell carcinoma and gastrointestinal tumor, second case is oesophageal adenocarcinoma with gastrointestinal tumor, and third case is oesophageal squamous cell cancer and gastric.

A Coexistence of Epithelial and Mesenchymal Neoplasm in A Tertiary Health Care Center. Synchronous Tumor in Gastro-Oesphagectomy Specimens- A Retrospective Analysis Read More »

Genetic work-up for the rare new mutations causing musculoskeletal and spine pain

1.1. Background: Spine pain is widespread due to degenerative disc disease and facet arthropathy. Most patients improve with supportive conservative care measures, including non-steroidal anti-inflammatories, physical therapy, short episodes of rest, and activity modification. Medical and interventional pain manage ment is reserved for those patients who do not improve within 4 to 6 weeks of standard spine care managed within the primary care setting, after which patients are typically referred to a specialist. Genetic conditions are rarely considered early in the differential diagnosis and may be easily missed in non-responsive patients. 1.2. Methods: We briefly de-scribe two illustrative cases of pa tients with a history of chronic musculoskeletal and spinal pain, whose delayed diagnosis led to improper utilization of medical resources until they were diagnosed correctly and targeted person alized care for their painful syndromes could be instituted. 1.3. Results: After a long history of physiotherapy for sever al years to alleviate muscular and spine pain, a patient with lack of proper control of the trunk and leg muscles causing difficul ties with getting up from a sitting position, walking, and climbing stairs was diagnosed with a new mutation in the KLHL40 gene associated with the pain syndrome of Nemaline Myopathy. A sec ond case a severe scoliosis with short femur leading to dwarfism through sonography investigations was diagnosed via mutation in exon 5 of the FGFR3 gene by WES and Sanger sequencing tests. An aborted fetus whose parents did not carry the mutant allele as sociated with Autosomal dominant thanatophoric dysplasia type I due to a de novo mutation of the FGFR3 gene associated with increased sensitivity of nociceptors such as TNF-α. 1.4. Conclusions: Genetic factors may play a more significant role in unrelenting musculoskeletal and spinal pain syndromes in indi viduals unresponsive to standard conservative care measures than previously thought. Genetic screening, counseling, and a combi nation of targeted interventions aimed at alleviating the harmful effect of the underlying gene defect and the disability associated with painful conditions of the musculoskeletal system affecting lo- http://www.acmcasereport.com/ 2 Volume 10 Issue 19 -2023 Case Report comotion and spinal deformity and balance should be considered early on mainly if the index of suspicion for an underlying genetic condition is high.

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