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April 19, 2025


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Uncategorized|Volume 14

Sepsis or Jarisch-Herxheimer Reaction? A Case of Clinical Overlap

1. Abstract The Jarisch-Herxheimer reaction (JHR) is an acute inflammatory response that may occur after initiating anti microbial therapy for spirochetal infections, most notably syphilis. Its clinical presentation often involving fever, hypotension, and systemic symptoms-can closely mimic sepsis, posing a diagnostic challenge

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LHX4 Mutation: New Perspective

1. Abstract Some transcription factors orchestrate the ontogeny of the pituitary gland, maintain the differentiated state and mediate the coordinated expression of specific cell type and their alteration can be involved in isolated and combined deficits. Among them, LHX4 gene mutations can manifest as a combined pituitary hormone deficiency and are associated with an ectopic posterior pituitary and/or a sella turcica defect.

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