A Case Report and Literature Review of Breast Sparganosis
1. Abstract Sparganosis is a global zoonotic parasitic disease caused by sparganum, a plerocercoid tapeworm larva of the genus Spirometra. Among them, breast sparganosis is a rare disease, accounting for less than 2% of the total number of human cases. The major common clinical presentation is the breast tumor-like mass, and preoperative diagnosis is typically […]
Mathematical Modeling of Histone Deacetylases to Predict their Response against Belinostat Drug Treatment for Smooth Muscle Cells Proliferation
1. Abstract 1.1. Background: The family of enzymes known as histone deacetylases (HDACs) serves as an objective target for regulating the phenotypic of smooth muscle cells (SMCs) and advanced smooth muscle cells (ASMCs).
Efficacy of Anti-HER2 Targeted Therapies on Peritoneal Metastasis of Lobular Mammary Carcinoma: A Case Report
1. Introduction Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer, comprising up to 15% of all cases. These tumors are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and HER2 negative.
Collapsing Glomerulopathy Following Moderna COVID-19 Vaccine and Response to Treatment
1. Background Over 13 billion doses of the COVID-19 vaccine have been administered worldwide. Though these vaccines have been proven safe and effective by large clinical trials, there is an emerging evidence of rare adverse events. We report here case of de-novo nephrotic range proteinuria and acute kidney injury caused by collapsing focal segmental glomerulosclerosis […]
A Case Report of HIV-Related Encephalitis with Psychiatric Presentation: Behavioral Anomalies, Differential Diagnosis and Therapeutic Strategies
1. Abstract The difference between a primary psychiatric disorder and the psychiatric manifestation of a defined medical condition is often blurred and represents an utmost clinical challenge, especially in the context of an emergency service in which it is essential to achieve a correct and timely differential diagnosis.
Evaluation of Clinical Significance of Vitamin B12 Status in Patients Admitted with Acute Febrile Illness Thrombocytopenia at Tertiary Care Hospital
1. Abstract 1.1. Background: Thrombocytopenia is one of the most important hematological manifestations of many infections which may present with pyrexia. Vitamin B12 deficiency is highly prevalent nutritional deficiency in India and it may also be associated with low levels of platelets. This study was planned to evaluate clinical significance of vitamin B12 status in […]
Cloning, Expression, and Dimer formation Assay of GANAB cDNA in Lung Cancer Cells
1. Abstract 1.1. Background: Glucosidase II is an endoplasmic reticulum heterodimer enzyme, a neutral glucosidase, involved in the trading and folding of newly synthesized glycoproteins in the endoplasmic reticulum. The destruction of GANAB leads to the accumulation of misfolded glycoproteins and the induction of unfolded protein responses. GANAB is also a key regulator of glycosylation.
Incidence of Periphral Neuropathy in Breast Cancer Women on Paclitaxel
1. Abstract 1.1. Background: Breast cancer is the most prevalence cause of cancer death among women and the fifth largest cause of cancer death globally, treatment of breast cancer include hormonal that can be change to other chemotherapy when the response is poor, Paclitaxel is the one of the most chemotherapy used in this reason […]
Pneumatosis Cystoides Intestinalis in Ulcerative Colitis; Histological Characteristic of the Cystic Structures
1. Abstract Pneumatosis cystoides intestinalis (PCI) is a rare disease characterized by multiple gas-filled cysts in the intestinal wall, and may be easily missed or misdiagnosed. We report here a case of 40-yearold man who was suffering from ulcerative colitis (rectal type) for 14 years. He was referred to the gastroenterology department of our hospital […]
A look back before looking ahead: Quality of A look back before looking ahead: Quality of Life (QoL) in women affected by complex vascular anomalies. Lessons learned to improve their health and well beingLife (QoL) in women affected
1. Abstract 1.1. Background: Patients with disabling complex vascular anomalies (VA) have decreased quality of life (QoL). 1.2. Objectives: To assess QoL of women with complex VA with the help of the global Well-Being Scale (QWBSA). 1.3. Method: Female adult patients from the vascular anomaly clinic of a single tertiary care center in Canada have […]