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May 19, 2025


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Review

Toxic Megacolon in A Patient with Ulcerative Colitis and A History of Hirschprung’s Disease Case Report

1. Introduction Hirschsprung’s disease (HD) is the most common cause of functional intestinal obstruction in paediatric patients. It is characterized by contiguous intestinal ganglionitis of the myenteric plexuses of Auerbach and the submucosal

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Spotlight on the Pathophysiological Trajectories Linked toAlzheimer’s Disease (AD): Blood-Brain Barrier (BBB);Neuroinflammation; APOE4 Allele and AD Insulin Resistance (IR) Pathogenic Link

1. Abstract Alzheimer’s disease (AD) is a predominant and incurable chronic debilitating neuro-degenerative disorder occupying more than 60% of all types of dementias. It is inaugurating by a cascade of events initiating from amnesic-typememory impairment and by gradually loss of cognitive and executive capacities, which is an intolerable problem for the patients and their familiars.

Spotlight on the Pathophysiological Trajectories Linked toAlzheimer’s Disease (AD): Blood-Brain Barrier (BBB);Neuroinflammation; APOE4 Allele and AD Insulin Resistance (IR) Pathogenic Link Read More »

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