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December 6, 2025


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Case Report

Proof of Efficacy and Safety of Activated NK Cell Immunotherapy (ANK Therapy) for Various Types of Cancer, and Investigation into The Possibility That PD-L1 Is Useful as A Biomarker for Predicting Efficacy

1. Introduction Activated natural killer cell immunotherapy (ANK therapy) is a treatment in which NK cells are extracted from the patient’s own blood, expanded, activated, and then returned to the body.

Proof of Efficacy and Safety of Activated NK Cell Immunotherapy (ANK Therapy) for Various Types of Cancer, and Investigation into The Possibility That PD-L1 Is Useful as A Biomarker for Predicting Efficacy Read More »

A Case of Familial Partial Lipodystrophy Type 3 with A Novel Pparg Variant of Unknown Significance

1. Abstract Familial partial lipodystrophy (FPLD) is a heterogeneous group of rare genetic disorders (estimated prevalence <1/100,000) characterized by a lipodystrophy phenotype combined with metabolic abnormalities such as insulin resistance and hypertriglyceridemia. Several subtypes have been described

A Case of Familial Partial Lipodystrophy Type 3 with A Novel Pparg Variant of Unknown Significance Read More »

A Rare Case of Mid-Ventricular and Apical Hypertrophic Cardiomyopathy with Hourglass Appearance on Echocardiogram

1. Abstract Hypertrophic obstructive cardiomyopathy (HOCM) is a genetically driven cardiac condition most often involving asymmetric septal hypertrophy. Mid-ventricular and apical variants are rare, accounting for less than 5% of cases in Western populations, and present unique diagnostic and prognostic challenges.

A Rare Case of Mid-Ventricular and Apical Hypertrophic Cardiomyopathy with Hourglass Appearance on Echocardiogram Read More »

An Alternative Approach to Current Guidelines: The Use of Top-Up Long-Acting Buprenorphine Injection for A Patient Presenting with Withdrawal Symptoms

1. Abstract A 34-year-old male patient with opioid use disorder (OUD), who was transitioned from daily oral buprenorphine/naloxone therapy.

An Alternative Approach to Current Guidelines: The Use of Top-Up Long-Acting Buprenorphine Injection for A Patient Presenting with Withdrawal Symptoms Read More »

Bronchoscopic Resection of Endotracheal Castleman Disease: A Rare Case Report

1. Abstract Castleman’s disease (CD) is an uncommon benign lymphoid hyperplasia, which was first reported by Benjamin Castleman in 1954. Pulmonary CD has been documented in the literature as a rare extranidal manifestation. We report a case of a 53-year-old woman with respiratory insufficiency presenting as an endotracheal lesion.

Bronchoscopic Resection of Endotracheal Castleman Disease: A Rare Case Report Read More »

Co-Occurrence of Acromioclavicular Joint Cyst and Rotator Cuff Re-Tear: Diagnostic and Therapeutic Challenges of A Case Report

1. Abstract Acromioclavicular cysts are an uncommon aetiology of shoulder pain, often concomitant with rotator cuff tears. Due to their low incidence, treatment guidelines remain unclear and are typically based on patient-specific factors.

Co-Occurrence of Acromioclavicular Joint Cyst and Rotator Cuff Re-Tear: Diagnostic and Therapeutic Challenges of A Case Report Read More »

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