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February 21, 2025


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Case Report

Trastuzumab Deruxtecan (T-Dxd) Combined with Local Therapy for Treatment of HR+/HER2+ Metastatic Breast Cancer with Liver and Distant Lymph Node Involvement: A Case Report

1. Abstract Breast cancer is the most prevalent cancer among women globally. Within breast cancer, the HR+/HER2+ subtype is particularly notable among luminal subtypes, as it shows resistance to both endocrine and anti-HER2 therapies. This is especially true for cases with local visceral metastasis, where the necessity of adding local therapy.

Trastuzumab Deruxtecan (T-Dxd) Combined with Local Therapy for Treatment of HR+/HER2+ Metastatic Breast Cancer with Liver and Distant Lymph Node Involvement: A Case Report Read More »

Treatment For Thrombocytopenia Complicated with Intracranial Venous Sinus Thrombosis and Bleeding with Eltrombopag: A Case Report

1. Abstract A case of primary immune thrombocytopenia (ITP) was reported, in which a patient developed intracranial venous sinus thrombosis accompanied by subarachnoid hemorrhage during oral administration of 25 mg/d of Eltrombopag. The patient discontinued the use of Eltrombopag and received symptomatic treatment with active anticoagulation, resulting in significant improvement.

Treatment For Thrombocytopenia Complicated with Intracranial Venous Sinus Thrombosis and Bleeding with Eltrombopag: A Case Report Read More »

Isolated Lunate Fracture Nonunion: A Case Report of Chronic Wrist Pain in a 37 Years Old Male

1. Abstract 1.1. Introduction Lunate fractures are considered rare to get fractured accounting for 0.5-1% of all carpal fractures. Usually they are accompanied with other wrist injuries rather than isolated. Usually patients will present late to seek medical advice and they will be complaining of limitation on in wrist motion and chronic pain. As a sequel if left untreated patient my develop avascular necrosis of the lunate.

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Hepatitis and Herpetic Encephalitis Complicated by Macrophage Activation Syndrome in an Immunocompetent Patient

1. Abstract Herpetic hepatitis and encephalitis are rare but severe forms of liver and brain infections caused by the herpes simplex virus (HSV). Often underdiagnosed due to their nonspecific symptoms and rarity, these infections can be life-threatening and lead to multiple complications. Although these conditions primarily affect immunocompromised individuals, rare cases have been reported in immunocompetent patients. Early recognition and treatment with antivirals like Acyclovir are crucial to improving the prognosis and preventing complications in patients with these conditions.

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Endovascular Superior Vena Cava Stenting As Effective Therapy of A Life Threatening Epistaxis in A Patient with Hereditary Hemorrhagic Telangiectasia

1. Abstract Indwelling port catheters are nowadays the main etiology of benign superior vena cava (SVC) syndrome. SVC obstruction increases the venous blood pressure upstream, and subsequently into the arterio-venous sac malformations of the nasal cavity, leading to the high risk of recurrent epistaxis in hereditary hemorrhagic telangiectasia (HHT) patients. In the present case, percutaneous SVC recanalization made possible to deal successfully with epistaxis in a HHT patient presenting with complete occlusion of SVC related to central venous catheter secondary misplacement into the azygos venous arch.

Endovascular Superior Vena Cava Stenting As Effective Therapy of A Life Threatening Epistaxis in A Patient with Hereditary Hemorrhagic Telangiectasia Read More »

The Mooji Effect of “Osborne-Cotterill Lesion” New Approach to Concept

1. Abstract 1.1. Introduction “Osborne-Cotterill Lesion” leaves an impression in the capitellum following injury or dislocation of the elbow. The clinical importance of this lesion is not yet recognized. We suggest a simple algorithm to measure its importance clinically and offer surgical treatment with bone graft and plating to prevent engagement of the radial head in this lesion calling this process of engagement “Mooji effect”.

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