April 8, 2025
Spotlight on the Pathophysiological Trajectories Linked toAlzheimer’s Disease (AD): Blood-Brain Barrier (BBB);Neuroinflammation; APOE4 Allele and AD Insulin Resistance (IR) Pathogenic Link
1. Abstract Alzheimer’s disease (AD) is a predominant and incurable chronic debilitating neuro-degenerative disorder occupying more than 60% of all types of dementias. It is inaugurating by a cascade of events initiating from amnesic-typememory impairment and by gradually loss of cognitive and executive capacities, which is an intolerable problem for the patients and their familiars.