Proximal humerus fractures account for 5-6% of all adult frac tures. There is increasing recognition given in regard to managing these fractures in the setting of elderly, low-energy falls as these events are contributing to the global impact of direct and indirect costs of osteoporosis and fragility fractures.
Expression of Catenin Delta 1 (CTNND1) in Pancreatic Cancer and Its Influence on Tumor Cell Biological Behavior
1.1. Objective: To explore the role of Catenin Delta 1 (CTNND1) in pancreatic cancer and its possible mechanism. 1.2. Methods: We selected CTNND1 as the research target us ing gene expression profile databases and bioinformatics analy sis methods. CTNND1 expression in the pancreatic cancer cell line PANC-1 was suppressed by siRNA technology, and various cell biological experiments were used to evaluate the impact of CTNND1 on cell proliferation, migration, invasion, apoptosis, and cell cycle. Meanwhile, the protein levels of epithelial-mesenchy mal transition (EMT) related biomarkers were detected to explore whether CTNND1 can regulate EMT in pancreatic cancer cells. 1.3. Results: We found that CTNND1 expression in pancreatic cancer cells was significantly increased. Knockdown of CTNND1 significantly reduced the proliferation, migration, and invasion ability of PANC-1 cells, increased the apoptosis rate, and inhib ited the cell cycle progression. In addition, CTNND1 knockdown could regulate EMT in pancreatic cancer cells. 1.4. Conclusion: Our research results reveal the important role of CTNND1 in pancreatic cancer and propose its possible mech anism of action. These findings provide a new theoretical basis for the treatment of pancreatic cancer, and CTNND1 may become a new target for pancreatic cancer treatment. However, more in depth research is still needed to clarify the specific role of CTN ND1 in pancreatic cancer and its detailed molecular mechanism.
We present a case of ST-segment myocardial infarction in a patient with anomalous single vessel coronary artery, i.e. right coronary artery originating from the left coronary artery. The patient under went successful primary percutaneous intervention of anomalies single vessel coronary artery without severe complications.
Acute compartment syndrome is a surgical emergency requiring in time management otherwise complications which may lead sever discomfort or to loss of limb can occur. In a study it has been found that acute compartment syndrome is present in 87 (7.73 %) of all tibial diaphyseal fractures with no significant difference in inci dence of acute compartment syndrome in type of fractures. Result of this study can be used to find the magnitude of this emergency condition in patient with fracture and the pre planning for such condition
Clinical determinants of outcome and respiratory management in COVID-19 mechanically ventilated patients with Acute Respiratory Distress Syndrome: A 15-month prospective observational study in a Greek Intensive Care Unit
1.1. Background: Covid-19 associated acute respiratory distress syndrome (CARDS) and prolonged mechanical ventilation im poses a major burden on affected critically ill individuals, in light of high mortality. We aimed to identify possible risk factors for mortality among the three categories of ARDS severity according to Berlin definition and to examine the effect of time on patients’ oxygenation and respiratory mechanics. 1.2. Methods: We prospectively investigated the clinical charac teristics and outcome of 196 consecutive mechanically ventilated patients with CARDS, along with oxygenation and respiratory me chanics, on ICU days 1, 3 and 7. 1.3. Results: ICU mortality accounted for 63.3%. Non-survivors were significantly older and presented higher disease severity on ICU admission and higher incidence of chronic obstructive pulmo nary disease (COPD), neurologic disease and immunosuppression. PaO2/FiO2 was significantly higher in the survivors group at all time points, whereas significant increase over time (day 7 vs day 1) was observed only in survivors group. Static respiratory system compliance was higher and driving pressure was lower in survi vors compared to non survivors, on days 3 and 7. Regarding the non-survivors group, oxygenation remained unchanged through different time points, while compliance reduced significantly and plateau and driving pressures increased through evolution of time. Mild, moderate and severe CARDS was reported in 16 (8.2%), 88 (44.9%) and 92 (46.9%) patients respectively. Incidence of obe sity was higher in severe CARDS. PEEP levels and plateau pres sures were higher in the severe CARDS, while respiratory system compliance and driving pressure did not differ among the CARDS categories. 1.4. Conclusions: In our case series, ICU mortality was high and increased accordingly to CARDS severity. Mortality risk factors included older age, COPD, neurological disorders and immuno suppression. Body mass index was significantly increased across CARDS severity. Trajectories of hypoxemia and respiratory me chanics were also associated with outcome