Issue 11

1.1. Background: Hepatic inflammation and inflammasome-me diated mechanisms are involved in the pathogenesis of Hepato cellular Carcinoma (HCC), and Absent in Melanoma 2 (AIM2) triggers activation of the inflammasome cascade. Until now, it re mains unclear whether and how AIM2 plays a role in HCC and Radiofrequency Ablation (RFA). This study aimed to investigate whether RFA induces pyroptosis in HCC through AIM2-inflam masome signaling in vivo and in vitro.

1.1. Background: Ischemic priapism is a rare condition with ful ly penile rigidity and severe pain. Blood trapping in the penis is a crucial pathophysiology for ischemic priapism, but the reason causing the blood trapping varies. This report presents a case of a 48-year-old male experiencing a vascular abnormality-relevant is chemic priapism during hemodialysis treated with a canerno-glan dular shunt

Severe headache is one of the quite common complication after a dural puncture procedure be it diagnostic (lumbar puncture) or un intentional (e.g., after epidural anaesthesia). Knowing that Postur al Puncture Headache (PDPH) most often becomes the culprit in most cases, many severe and serious etiologists should be assessed though its frequently rare due to other causes of headache after Du ral puncture. (e.g., tension headache, migraine, and PDPH) known as the most common. It’s very easy to misdiagnose PDPH from PEISH due to the clinical similarities in manifestation. However, we are presenting a case of this rare complication by presenting the difference between PDPH and PEISH.

Individuals with bilateral transfemoral amputations experience great difficulty in prosthetic ambulation in their community be cause of high energy consumption during walking. We present the case of a 47-year-old male with bilateral transfemoral amputation who gradually became more fatigued when walking with pros theses 11 years after completing his first prosthetic training.

The history of mankind dates back thousands of years, and only in recent years has there been a rapid increase in the percentage of cases, including deformities of the feet and spine. If 60 years ago, flat feet were considered in conjunction with the aging of the body, age-related causes of weight loss, today deformities are already diagnosed in preschool children.