A Novel Role of AIM2 Inflammasome-Mediated Pyroptosis in Radiofrequency Ablation of Hepatocellular Carcinoma
1.1. Background: Hepatic inflammation and inflammasome-me diated mechanisms are involved in the pathogenesis of Hepato cellular Carcinoma (HCC), and Absent in Melanoma 2 (AIM2) triggers activation of the inflammasome cascade. Until now, it re mains unclear whether and how AIM2 plays a role in HCC and Radiofrequency Ablation (RFA). This study aimed to investigate whether RFA induces pyroptosis in HCC through AIM2-inflam masome signaling in vivo and in vitro.