The Physics of Darwinian Evolution
1. Abstract This paper describes the physical (thermodynamic) laws that govern Darwinian Evolution. When one understands how to apply these laws of physics, it becomes clear how clinical, experimental, and empirical examples of Darwinian Evolution behave the way they do. In particular, this paper shows which thermodynamic laws need to be applied to model and […]
A Case Report of XLHR Caused by a PHEX Intron Variant Responsive to Burosumab: A Four-Year Follow-Up
1. Abstract 1.1. Introduction: X-linked hypophosphatemic rickets (XLHR) is a dominant inherited disease characterized by renal phosphate wasting and impairment of vitamin D activation. We present a clinical case of a patient with XLHR as a consequence of an intron pathogenic variant in the PHEX gene.